New York: November 19, 2019 – The Children’s Tumor Foundation (CTF), an innovative and global neurofibromatosis (NF) research foundation announced today a collaboration with DELopen, a DNA-encoded library technology platform sponsored by WuXi AppTec, a leading global provider of R&D and manufacturing services enabling companies in the pharmaceutical, biotechnology and medical device industries. DELopen will provide researchers free access to billions of molecules to seek insights into and develop therapies for the treatment of NF under grants covered by CTF’s Drug Discovery Fund.

The Children’s Tumor Foundation has issued a renewed focus on investigator-initiated awards through its Discovery Fund, and is dedicating considerable support for the innovative and leading-edge research that will more quickly translate into new clinical treatments. CTF’s Drug Discovery Initiative, in partnership with the DELopen initiative, will provide a unique opportunity for the neurofibromatosis research community to access this technology for their investigations.

The DELopen platform currently provides free access to nearly 2.8 billion molecules for biomedical research to the academic and nonprofit life science communities. The Children’s Tumor Foundation will offer an in-vitro Drug Discovery Initiative Award for up to $40K, in conjunction with the use and implementation of DELopen for NF research.

“The unprecedented availability of compounds for target validation, mechanistic studies, and academic drug discovery has transformative potential,” stated Richard Lerner, MD, chair of the DELopen advisory board, Institute Professor at Scripps Research, and co-inventor of the technology. “Accessing compounds at this scale will stimulate innovation to tackle tough diseases like neurofibromatosis. We are indeed pleased to be part of the Drug Discovery Initiative to bring effective medicines to NF patients.”

“The partnership between the Children’s Tumor Foundation and DELopen offers unique opportunities to the NF research community to identify even better specific therapies for the patients in the NF community,” noted Annette Bakker, PhD, President of the Children’s Tumor Foundation. “We look forward to this collaboration in our mission to eradicate NF.”

Neurofibromatosis, or NF, is a genetic disorder that affects 1 in 3,000 births and causes tumors to grow on nerves throughout the body. It can lead to blindness, deafness, bone abnormalities, disfigurement, learning disabilities, disabling pain, and cancer. There are no approved treatments for NF available yet.

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To learn more, please visit ctf.org.

About Children’s Tumor Foundation

The Children’s Tumor Foundation is a 501(c)(3) not-for-profit organization dedicated to funding and driving innovative research that will result in effective treatments for the millions of people worldwide living with neurofibromatosis (NF), a term for three distinct disorders: NF1, NF2, and schwannomatosis. NF causes tumors to grow on nerves throughout the body and may lead to blindness, deafness, bone abnormalities, disfigurement, learning disabilities, disabling pain, and cancer. NF affects 1 in every 3,000 births across all populations equally. There is no cure yet – but the Children’s Tumor Foundation mission of driving research, expanding knowledge, and advancing care for the NF community fosters our vision of one day ending NF. For more information, please visit http://www.ctf.org.

About DELopen

DELopen is a platform connecting industry and academic research institutions to promote the sharing of scientific research information and the protection of intellectual property. Through DELopen, researchers and institutions engaged in the development of new drugs with DNA-encoded library (DEL) technology can more quickly conduct early new drug development and advance the results of early development to commercialization. For more information on DELopen, please visit https://delopen.org.

Media Contact:

Simon Vukelj

Chief Marketing Officer

Children’s Tumor Foundation

Tel: (212) 344-7568

Email: [email protected]

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.



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